![]() ![]() Finally, the addition of ACTH completed a putative multipotent precursor model that has been recently named pro-opiomelanocortin. The finding of a more potent opioid substance in the pituitary (beta-endorphin) that comprises the last 31 amino acids of beta-LPH shed a new light on the hypothesis proposed earlier which gave to beta-LPH a role as a precursor molecule. The isolation of such substances in the brain, first named enkephalins, revealed through their amino acid sequence their structural homology with the pituitary lipolytic hormones. The demonstration of specific brain opiate receptors led to the hypothesis of the existence of endogenous opiate ligands which could act as neurotransmittors. The discovery of endorphins brought together two fields of research that were not related: the opiates and the so-called pituitary lipotropic hormones. This concept was simultaneously proposed for proinsulin and applied later to other polypeptide hormones. You'll feel the momentum with every stride.The knowledge of the amino acid sequence of both beta-lipotropin (beta-LPH) and gamma-LPH was the starting point that led to the hypothesis, considered revolutionary in 1967, that hormonal precursors exist. Responsive Natural Ride: The SPEEDROLL creates a lively rolling feel underfoot to provide an instantly responsive and natural ride.The energy efficiency means less fatigue so you can run further and faster. Ultralight Energetic Cushion: Take your training and racing to new levels with an incredible combo of new ultralight PeBax®-based PWRRUN PB cushioning and the energetic power transfer of a composite plate.Light Comfy Fit: A breathable FORMFIT engineered mesh upper with 3D printed structure ensures a locked-in fit that's light and comfortable on foot.If these aren't you're perfect fit, exchange within 90 days. VIP 90-Day Perfect Fit Promise: VIP Family members can test run the Saucony Endorphin Speed for up to 90 days.Perfect For: Tempo running, workouts, daily running and racing on roads and paved trails.Midsole Drop: The Men's Saucony Endorphin Speed has a heel to toe drop of 8 mm.Cushion Level: Max Cushion offers maxed out softness in every step to reduce fatigue even when you're pushing your running to the next level. ![]() ![]() Running Shoe Support: Your Endorphin Speed is a neutral running shoe that's perfect for runners with medium to high arches that like a natural feet in their running shoe. ![]()
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